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10-Year Cardiovascular Risk Assessment in RA

Arthritis Res Ther; ePub 2018 Dec 3; Bissell, et al

A recent study demonstrates the utility of carotid-MRI in rheumatoid arthritis (RA), reporting an association between 3-dimensional measures in particular and cardiovascular (CV) risk scores, individual traditional CV risk factors, and RA disease duration. Therefore, carotid-MRI in RA is a promising research tool in the investigation of CVD. 64 patients with RA and no history of CV disease/diabetes mellitus were assessed for a RA and CV profile, including homeostasis model assessment-estimated insulin resistance (HOMA-IR) and N-terminal pro-brain natriuretic peptide (NT-proBNP). All underwent carotid-MRI (3 T), and were compared to 24 healthy controls. Researchers found:

  • There were no significant differences in carotid arterial wall measurements between patients with RA and controls.
  • Wall and luminal volume correlated with 10-year CV risk scores.
  • In univariable analysis, carotid-MRI volumetric measures predominantly were associated with traditional CV risk factors including age, ever-smoking, and HOMA-IR.
  • In multivariable linear regression models, age was independently associated with wall volume and luminal volume, and RA disease duration was associated with luminal volume.
Citation:

Bissell L-A, Erhayiem B, Fent G, et al. Carotid artery volumetric measures associate with clinical ten-year cardiovascular (CV) risk scores and individual traditional CV risk factors in rheumatoid arthritis; a carotid-MRI feasibility study. [Published online ahead of print December 3, 2018]. Arthritis Res Ther. doi:10.1186/s13075-018-1761-2.