Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

LV Abnormalities Common in Giant Cell Arteritis

Semin Arthritis Rheum; ePub 2018 May 9; Kermani, et al

In a cohort of patients with giant cell arteritis (GCA), large-vessel (LV) abnormalities on first imaging were common, according to recent study. Furthermore, development of new arterial lesions occurred in patients with arterial abnormalities at first imaging, often in the absence of symptoms of active disease. Clinical and imaging data from patients with GCA (including subjects diagnosed by LV imaging) enrolled in a prospective, multicenter, longitudinal study and/or a randomized clinical trial were included (n=187 with GCA; 146 [78%] female, mean [±SD] age at diagnosis 68.5±8.5 years; 39% diagnosed by LV imaging). Researchers found:

  • At least 1 arterial lesion was present in 123 (66%) on the first study.
  • The most frequently affected arteries were subclavian (42%), axillary (32%), and thoracic aorta (20%).
  • In 106 patients (57%) with serial imaging, new arterial lesions were noted in 41 patients (39%), all of whom had a baseline abnormality, over a mean (±SD) follow-up of 4.39 (2.22) years.
  • New abnormalities were observed in 33% patients by year 2; clinical features of active disease were present at only 50% of these cases.


Kermani TA, Diab S, Sreih AG, et al. Arterial lesions in giant cell arteritis: A longitudinal study. [Published online ahead of print May 9, 2018]. Semin Arthritis Rheum. doi:10.1016/j.semarthrit.2018.05.002.

This Week's Must Reads

CCP Level and Progression to Rheumatoid Arthritis, Arthritis Care Res; ePub 2018 Dec 20; Ford, et al

Evaluation of Cytokine Profile in Patients with RA , Clin Rheumatol; ePub 2018 Dec 1; Alex, et al

Personalized Chronic Disease Risk Tool Evaluated, Patient Educ Couns; ePub 2017 Dec 10; Marshall, et al

10-Year Cardiovascular Risk Assessment in RA, Arthritis Res Ther; ePub 2018 Dec 3; Bissell, et al

Alcohol Use Habits of Patients with RA Evaluated, BMJ Open; 2018 Dec 14; Larsson, et al

Must Reads in Pain

Assessing Back Pain Criteria in Psoriatic Arthritis, Ann Rheum Dis; 2018 Nov; Yap, Ye, et al

Knee Pain and Physical Activity Preference Examined, Osteoarthritis Cartilage; ePub 2018 Oct 15; Pinto, et al

Study Identifies 4 Pain Susceptibility Phenotypes , Arthritis Rheumatol; ePub 2018 Oct 11; Carlesso, et al

Varus Thrust Linked with Worsening Knee Pain, Arthritis Care Res; ePub 2018 Sep 22; Wink, et al

Does Exercise Contribute to Radiographic Worsening?, Arthritis Care Res; ePub 2018 Sep 20; Jayabalan, et al