Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Low BMD, Coronary Artery Calcium Link Examined

Osteoporos Int; ePub 2018 Apr 27; Ahmadi, et al

Lower bone mineral density (BMD) levels are independently associated with the severity of coronary artery calcium (CAC) that predicts mortality, according to a recent study that investigated the relation of BMD levels with CAC and mortality in both genders across ethnicities. Researchers assessed 5,590 consecutive at-risk subjects without known coronary artery disease (CAD) (age 57 ± 12, 69% male), who underwent non-enhanced cardiac computed tomography, and were followed for a mean of 8 years. CAC stratified based on the severity to CAC 0, 1–100, 101–400, and 400+. Low-BMD levels were defined as levels below median (180 mg/cm3). They found:

  • BMD levels were proportionally lowering with the severity of CAC in both genders, especially in postmenopausal women.
  • The risk of each standard deviation reduction in BMD levels increased with the severity of CAC, as compared to CAC=0 across ethnicities.
  • Low BMD levels were an independent predictor of mortality and event-free survival rate decreased from 99% in those within normal BMD levels to 93% in those with low BMD levels.
  • Furthermore, a significant link between low BMD levels and CAC >0 with increased risk of mortality was noted.


Ahmadi N, Mao SS, Hajsadeghi F, et al. The relation of low levels of bone mineral density with coronary artery calcium and mortality. [Published online ahead of print April 27, 2018]. Osteoporos Int. doi:10.1007/s00198-018-4524-7.

This Week's Must Reads

CCP Level and Progression to Rheumatoid Arthritis, Arthritis Care Res; ePub 2018 Dec 20; Ford, et al

Evaluation of Cytokine Profile in Patients with RA , Clin Rheumatol; ePub 2018 Dec 1; Alex, et al

Personalized Chronic Disease Risk Tool Evaluated, Patient Educ Couns; ePub 2017 Dec 10; Marshall, et al

10-Year Cardiovascular Risk Assessment in RA, Arthritis Res Ther; ePub 2018 Dec 3; Bissell, et al

Alcohol Use Habits of Patients with RA Evaluated, BMJ Open; 2018 Dec 14; Larsson, et al

Must Reads in Osteoporosis

Study: Veterans Affairs DXA Testing Ineffective, Mayo Clin Proc; 2018 Dec; Colón-Emeric, et al

US, Canadian Osteoporosis Screening Compared, J Bone Miner Res; ePub 2018 Dec 7; Crandall, et al

Poor Sleep Quality and Fracture Risk Examined, J Bone Miner Res; ePub 2018 Nov 21; Cauley, et al

Impact of Prescription Drugs on Fragility Fractures, Osteoporos Int; 2018 Dec; Munson, et al

Overuse of Osteoporosis Pharmacotherapy Evaluated , Arch Osteoporosis; 2018 Sep 28; Hall, Wright, et al