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Risk Factor Profiles Assessed for Radiographic OA

Osteoarthritis Cartilage; ePub 2018 Dec 28; Wei, et al

Risk factor profiles for medial and lateral tibiofemoral radiographic osteoarthritis (ROA) are different, according to a recent study and, therefore, these results can provide a framework for the development of targeted prevention and potential treatment strategies for specific knee OA subtypes. Knees without medial or lateral tibiofemoral ROA at baseline were followed for 60 months in Multicenter Osteoarthritis Study (MOST) and for 48 months in Osteoarthritis Initiative (OAI). They found:

  • Of 2,016 participants in MOST, 436 and 162 knees developed medial or lateral tibiofemoral ROA, respectively.
  • Obesity and varus malalignment were 95% and 466% more strongly associated with incident medial tibiofemoral ROA than with lateral tibiofemoral ROA, respectively (ratios of rate ratios [RRs], 1.95 and 5.66).
  • In contrast, the associations of female sex and valgus malalignment with incident medial tibiofemoral ROA were weaker or in an opposite direction compared with lateral tibiofemoral Osteoarthritis (OA) (ratios of RRs, 0.40 and 0.20, respectively).
  • Older age tended to show a weaker association with incident medial tibiofemoral ROA than with incident lateral tibiofemoral ROA.
  • These findings were closely replicated in OAI.
Citation:

Wei J, Gross D, Lane NE, et al. Risk factor heterogeneity for medial and lateral compartment knee osteoarthritis: Analysis of two prospective cohorts. [Published online ahead of print December 28, 2018]. Osteoarthritis Cartilage. doi:10.1016/j.joca.2018.12.013.