Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Low Magnesium Intake, Worse Knee OA Pain Linked

Osteoarthritis Cartilage; ePub 2018 Feb 15; Shmagel, et al

Lower magnesium intake was associated with worse pain and function in knee osteoarthritis (OA), especially among individuals with low fiber intake, a recent study found. Researchers investigated the associations between knee pain/function metrics and magnesium intake from food and supplements in 2,548 Osteoarthritis Initiative cohort participants with prevalent radiographic knee OA (Kellgren-Lawrence score ≥2). Magnesium intake was assessed by Food Frequency Questionnaire at baseline. They found:

  • Among participants with baseline radiographic knee OA, the mean total magnesium intake was 309.9 mg/day (SD 132.6) for men, and 287.9 mg/day (SD 118.1) for women, with 68% of men and 44% of women below the estimated average requirement.
  • Subjects with lower magnesium intake had worse knee OA pain and function scores, throughout the 48 months.
  • After adjustment for age, sex, race, BMI, calorie intake, fiber intake, pain medication use, physical activity, renal insufficiency, smoking, and alcohol use, lower magnesium intake remained associated with worse pain and function outcomes.
  • The association between magnesium intake and knee pain and function scores was strongest among subjects with low fiber intake.

Citation:

Shmagel A, Onizuka N, Langsetmo L, et al. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: Data from the Osteoarthritis Initiative. [Published online ahead of print February 15, 2018]. Osteoarthritis Cartilage. doi:10.1016/j.joca.2018.02.002.

This Week's Must Reads

Predictors of Discordance Between Patients with RA, Arthritis Care Res; ePub 2018 Nov 30; Challa, et al

Smoking Linked with Higher Disease Activity in RA, J Rheumatol; ePub 2018 Dec 1; Gianfrancesco, et al

Chronic Opioid Use Doubled Among Patients with RA, Arthritis Rheumatol; ePub 2018 Nov 26; Lee, et al

RA Telephone Education Program is Well Received, Musculoskeletal Care; ePub 2018 Dec 5; Farley, et al

Autoantibodies to PAD2 Linked with Less Severe RA, Front Immunol; ePub 2018 Nov 20; Darrah, et al

Must Reads in Osteoarthritis

Diabetes, Abnormal Glucose Metabolism, and RKOA, Arthritis Care Res; ePub 2018 Nov 12; Rogers-Soeder, et al

Arthritis Prevalence Among Adults with Prediabetes, MMWR; 2018 Nov 9; Sandoval-Rosario, et al

Benefits of Walking for Adults with Arthritis, Arthritis Care Res; ePub 2018 Oct 22; Hootman, et al

Link Found Between Viral Pathogens and Arthritis, Int J Rheumatol; 2018 Oct 1; Shmagel, et al

Diabetics Show Accelerated Knee Joint Degeneration, Skeletal Radiol; ePub 2018 Oct 24; Neumann, et al