Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

T2D Risk in PsA Higher than in General Population

Rheumatology (Oxford); ePub 2018 Sep 6; Charlton, et al

The development of type 2 diabetes (T2D) in an incident population of patients with psoriatic arthritis (PsA) is significantly higher than in psoriasis alone or in a general population, according to a recent study, whereas the increased risk of cardiovascular disease in PsA and psoriasis is similar. Incident PsA patients aged 18–89 years were identified in a clinical practice research databank between 1998 and 2014 and were matched (1:4 ratio) to a general population cohort and psoriasis cohort. The incidence of T2D, cerebrovascular disease, ischemic heart disease, and peripheral vascular disease (PVD) was calculated for each study cohort. Researchers found:

  • 6,783 incident cases of PsA were identified.
  • The risk of T2D was significantly higher in the PsA cohort than in the general population and the psoriasis cohorts.
  • The incidence of ischemic heart disease, peripheral vascular disease, and the 3 cardiovascular outcomes combined in the PsA cohort was significantly higher than in the general population.
  • No significant differences in risk were observed between the PsA and psoriasis cohorts for any cardiovascular outcome.


Charlton R, Green A, Shaddick G, et al. Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis: A population-based cohort study. [Published online ahead of print September 6, 2018]. Rheumatology (Oxford). doi:10.1093/rheumatology/key286.

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