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Smoking, Obesity Link with Sjögren Syndrome Gauged

J Rheumatol; ePub 2019 Jan 15; Servioli, Maciel, et al

Current smoking was inversely associated with case/control status in primary Sjögren syndrome (pSS), while body mass index (BMI) lacked any association, according to a recent population-based cohort study. Olmsted County, MN residents (n=106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex. Researchers found:

  • Current smokers were less likely to be pSS cases (odds ratio [OR] 0.34), while there was no association between former smoking and case/control status (OR 1.27) compared to never smokers.
  • Smoking status was not associated with antinuclear antibody, anti-Sjögren-syndrome-related antigen A (anti-SSA), anti-Sjögren syndrome type B (anti-SSB), or rheumatoid factor positivity.
  • OR for obesity was 0.79.


Servioli L, Maciel G, Nannani C, et al. Association of smoking and obesity on the risk of developing primary Sjögren syndrome: A population-based cohort study. [Published online ahead of print January 15, 2019]. J Rheumatol. doi:10.3899/jrheum.180481.