Clinical Edge

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Psoriasis Linked with Two Foot/Ankle Conditions

RMD Open; 2018 May 21; Lewinson, et al

Patients with psoriasis can have foot and ankle tendinopathy or enthesopathy without having psoriatic arthritis, presenting a diagnostic challenge to physicians, a recent study found. Patients with cutaneous psoriasis and a general population cohort were identified in The Health Improvement Network, a general practice medical records database. All patients with psoriatic arthritis were excluded. Cox proportional-hazards models (α=0.05) estimated the hazard ratio (HR) for development of foot and ankle tendinopathy or enthesopathy among patients with psoriasis, with adjustment for numerous covariates. Researchers found:

  • In total, 78,630 patients with cutaneous psoriasis and 5,983,338 persons from the general population were identified.
  • In an unadjusted model, patients with cutaneous psoriasis had a 25% increased risk of developing foot and ankle tendinopathy or enthesopathy compared with the general population (HR 1.25).
  • The HR remained unchanged and statistically significant after adjusting for covariates, and in sensitivity analyses.

Citation:

Lewinson RT, Vallerand IA, Parsons LM, et al. Psoriasis and the risk of foot and ankle tendinopathy or enthesopathy in the absence of psoriatic arthritis: A population-based study. RMD Open. 2018;4(1):e000668. doi:10.1136/rmdopen-2018-000668.