Lower volumetric bone mineral density (vBMD) was associated with increased all-cause mortality in African-American men with type 2 diabetes (T2D), independent of other risk factors for mortality including subclinical atherosclerosis, according to a recent study. Associations between vertebral fractures and vBMD with all-cause mortality were examined in 675 participants with T2D (391 women and 284 men) in the African American-Diabetes Heart Study (AA-DHS). Lumbar and thoracic vBMD were measured using quantitative computed tomography (QCT). Vertebral fractures were assessed on sagittal CT images. Associations of vertebral fractures and vBMD with all-cause mortality were determined in sex-stratified analyses and in the full sample. Researchers found:
- After mean 7.6 ± 1.8-year follow-up, 59 (15.1%) of women and 58 (20.4%) of men died.
- In men, vBMD was inversely associated with mortality in the fully adjusted model: lumbar hazard ratio (HR) per standard deviation (SD) = 0.70 and thoracic HR per SD = 0.71.
- Only trends toward association between vBMD and mortality were observed in the combined sample of men and women, as significant associations were absent in women.
- Vertebral fractures were not associated with mortality in either sex.
Lenchik L, Register TC, Russell GB, et al. Volumetric bone mineral density of the spine predicts mortality in African-American men with type 2 diabetes. Osteoporos Int. 2018;29(9):2049-2057. doi:10.1007/s00198-018-4578-6.