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Diabetes, Abnormal Glucose Metabolism, and RKOA

Arthritis Care Res; ePub 2018 Nov 12; Rogers-Soeder, et al

Diabetes mellitus (DM) and higher levels of biomarkers of abnormal glucose metabolism were not associated with increased odds of incident radiographic knee osteoarthritis (RKOA) after adjusting for body mass index (BMI), according to a recent study. Participants (mean age 60.6±7.8 years; mean BMI 29.1±4.9 kg/m2) were from the Multicenter Osteoarthritis Study (MOST) and did not have RKOA at baseline. A random sample (n=987) stratified by BMI was selected. Baseline serum fasting glucose and insulin resistance (homeostasis model of assessment [HOMA‐IR]) were measured. Participants were categorized as having DM based on self‐report, use of medication, or fasting glucose >126 mg/dL. Incident RKOA was assessed at 3 follow up visits (30, 60, 84 months). Researchers found:

  • After adjustment for BMI, the odds of incident RKOA were not associated with baseline DM status nor with levels of fasting glucose and HOMA‐IR overall and in men.
  • In women, HOMA‐IR was inversely associated with odds of incident RKOA (adjusted OR 0.80).

Rogers‐Soeder TS, Lane NE, Walimbe M, et al. Association of diabetes mellitus and biomarkers of abnormal glucose metabolism with incident radiographic knee osteoarthritis. [Published online ahead of print November 12, 2018]. Arthritis Care Res. doi:10.1002/acr.23809.