Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Diabetes, Abnormal Glucose Metabolism, and RKOA

Arthritis Care Res; ePub 2018 Nov 12; Rogers-Soeder, et al

Diabetes mellitus (DM) and higher levels of biomarkers of abnormal glucose metabolism were not associated with increased odds of incident radiographic knee osteoarthritis (RKOA) after adjusting for body mass index (BMI), according to a recent study. Participants (mean age 60.6±7.8 years; mean BMI 29.1±4.9 kg/m2) were from the Multicenter Osteoarthritis Study (MOST) and did not have RKOA at baseline. A random sample (n=987) stratified by BMI was selected. Baseline serum fasting glucose and insulin resistance (homeostasis model of assessment [HOMA‐IR]) were measured. Participants were categorized as having DM based on self‐report, use of medication, or fasting glucose >126 mg/dL. Incident RKOA was assessed at 3 follow up visits (30, 60, 84 months). Researchers found:

  • After adjustment for BMI, the odds of incident RKOA were not associated with baseline DM status nor with levels of fasting glucose and HOMA‐IR overall and in men.
  • In women, HOMA‐IR was inversely associated with odds of incident RKOA (adjusted OR 0.80).
Citation:

Rogers‐Soeder TS, Lane NE, Walimbe M, et al. Association of diabetes mellitus and biomarkers of abnormal glucose metabolism with incident radiographic knee osteoarthritis. [Published online ahead of print November 12, 2018]. Arthritis Care Res. doi:10.1002/acr.23809.

This Week's Must Reads

Examining Brain Correlates of Clinical Pain in RA, Arthritis Care Res; 2019 Feb; Lee, Fine, et al

Obesity/Weight Loss Linked to Mortality Risk in RA, Clin Exp Rheumatol; ePub 2019 Jan 18; Baker, et al

Study Does Not Back MRI-Guided Treatment Strategy, JAMA; ePub 2019 Feb 5; Møller-Bisgaard, et al

Remission Frequency and LDA in Patients with RA, Semin Arthritis Rheumatol; ePub 2018 Dec 28; Scott, et al

Comparison of Risk Calculators for CV Disease in RA, J Rheumatol; 2019 Feb; Wahlin, Innala, et al

Must Reads in Mixed Topics

Smoking, Obesity Link with Sjögren Syndrome Gauged, J Rheumatol; ePub 2019 Jan 15; Servioli, Maciel, et al

Glenohumeral Osteoarthritis and Mental Health, J Shoulder Elbow Surg; ePub 2018 Dec 12; Kohan, et al

RA and Mortality in End Stage Renal Disease, J Clin Rheumatol; ePub 2018 Dec 5; Paudyal, et al

Gout Independently Linked with Dementia in Elderly, BMC Geriatr; ePub 2018 Nov 14; Singh, Cleveland

Diabetes, Abnormal Glucose Metabolism, and RKOA, Arthritis Care Res; ePub 2018 Nov 12; Rogers-Soeder, et al