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Predictors of Disease Activity, Quiescence in SLE

Lupus Sci Med; ePub 2018 Nov 2; Giannakou, et al

African American ethnicity and high disease activity at baseline predict chronic activity in systemic lupus erythematosus (SLE), regardless of treatment, years of education, and income, a recent study found. Higher education, low disease activity at baseline, and male sex predict long quiescence. Patients enrolled in the Hopkins Lupus Cohort from 1987 to 2012, who attended at least 3 visits per year during 3 consecutive years following baseline and had available information on disease activity were included (n=916). Patterns of SLE disease activity over the 3-year period were defined as: persistent long quiescent (pLQ), persistent relapsing-remitting (pRR), persistent chronic active (pCA), and mixed based on Modified SLE Disease Activity Index (M-SLEDAI). Researchers found:

  • In the multivariate analysis, African American ethnicity and baseline SLEDAI remained significant predictors of pCA.
  • Higher education (>12 years) and lower baseline SLEDAI were significant predictors of pLQ, while African American and female patients were less likely to achieve pLQ.

Giannakou I, Chatzidionysiou K, Magder LS, Györi N, van Vollenhoven R, Petri MS. Predictors of persistent disease activity and long quiescence in systemic lupus erythematosus: Results from the Hopkins Lupus Cohort. [Published online ahead of print November 2, 2018]. Lupus Sci Med. doi:10.1136/lupus-2018-000287.