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Patients with SSc and Pulmonary Hypertension Risk

J Rheumatol; ePub 2018 Oct 1; Hsu, Chung, et al

Risk factors for poor outcome in patients with systemic sclerosis (SSc) who are at risk for pulmonary hypertension (PH) were similar to others with SSc-PH and SSc-pulmonary arterial hypertension, a recent study found. Other risk factors were male sex, diffusing capacity of the lungs for carbon monoxide (DLCO)< 50%, exercise oxygen desaturation, and pericardial effusions. This according to researchers who sought to identify predictors of mortality and cardiopulmonary hospitalizations in patients at risk for PH and enrolled in PHAROS, a recent prospective cohort study to investigate the natural history of PH in SSc. They found:

  • Of the 236 at-risk subjects who were followed for a median of 4 years, 35 developed PH after entering PHAROS (reclassified as PH group).
  • In the at-risk group, higher mortality was strongly associated with male sex, low %DLCO, exercise oxygen desaturation, anemia, abnormal dyspnea scores, and baseline pericardial effusion.
  • Risks for cardiopulmonary hospitalization were associated with increased dyspnea and pericardial effusions, although PH patients with DLCO <50% had the highest risk of cardiopulmonary hospitalizations.

Citation:

Hsu VM, Chung L, Hummers LK, et al. Risk factors for mortality and cardiopulmonary hospitalization in systemic sclerosis patients at risk for pulmonary hypertension, in the PHAROS Registry. [Published online ahead of print October 1, 2018]. J Rheumatol. doi:10.3899/jrheum.180018.

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