Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

First EHR Algorithm Will Help Identify SLE Patients

Arthritis Care Res; ePub 2017 Apr 10; Barnado, et al

Researchers developed and validated the first electronic health record (EHR) algorithm that incorporates laboratory values and medications with the systemic lupus erythematosus (SLE) Internal Classification of Diseases, Ninth Revision (ICD-9) code to accurately identify patients with SLE, according to a recent study. They used Vanderbilt's Synthetic Derivative, a de-identified version of the EHR, with 2.5 million subjects, selecting all individuals with at least 1 SLE ICD-9 code, yielding 5,959 individuals. In order to create a training set, 200 subjects were randomly selected for chart review. A subject was defined as a case if diagnosed with SLE by a rheumatologist, nephrologist, or dermatologist. They found:

  • The algorithm with the highest positive predictive values at 95% in the training set and 91% in the validation set was 3 or more counts of the SLE ICD-9 code, antinuclear antibody-positive, and ever use of both disease-modifying antirheumatic drugs and steroids, while excluding individuals with systemic sclerosis and dermatomyositis ICD-9 codes.


Barnado A, Casey C, Carroll RJ, Wheless L, Denny JC, Crofford LJ. Developing electronic health record algorithms that accurately identify patients with systemic lupus erythematosus. [Published online ahead of print April 10, 2017]. Arthritis Care Res. doi:10.1002/acr.22989.

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Predictors of Discordance Between Patients with RA, Arthritis Care Res; ePub 2018 Nov 30; Challa, et al

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Chronic Opioid Use Doubled Among Patients with RA, Arthritis Rheumatol; ePub 2018 Nov 26; Lee, et al

RA Telephone Education Program is Well Received, Musculoskeletal Care; ePub 2018 Dec 5; Farley, et al

Autoantibodies to PAD2 Linked with Less Severe RA, Front Immunol; ePub 2018 Nov 20; Darrah, et al

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Screening for Cognitive Dysfunction Risk in SLE, Lupus; ePub 2018 Nov 27; Chalhoub, Luggen

Depression in African American Women with SLE, Lupus; ePub 2018 Nov 27; Jordan, Thompson, et al

Psychosis Manifestation in Patients with SLE, Arthritis Rheumatol; ePub 2018 Oct 30; Hanly, et al

Frequent ED Utilization Among Persons with SLE, Arthritis Care Res; ePub 2018 Oct 8; Lee, Lin, et al

Child-Onset SLE, Myopericardial Incidences Linked, Lupus; ePub 2018 Oct 14; Chang, Xiao, et al