Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Does Exercise Contribute to Radiographic Worsening?

Arthritis Care Res; ePub 2018 Sep 20; Jayabalan, et al

In persons with or at higher risk for knee osteoarthritis (OA), age, sex, body mass index (BMI), and pain – but not objectively measured average daily minutes of sedentary or moderate‐vigorous activity – were associated with subsequent worsening of Kellgren-Lawrence (KL) grade, a recent study found. In Osteoarthritis Initiative participants with or at higher risk for knee OA enrolled in an accelerometer sub-study at 48m (study baseline), physical activity was measured by uniaxial accelerometer (ActiGraph GT1M). Radiographic progression was defined as any 48m‐96m KL grade worsening. Researchers found:

  • 1,206 persons [mean age 64 years (SD 9), 631 (52%) women, BMI 28 (5), average daily sedentary activity 602 minutes (86), light activity 284 minutes (75), moderate‐vigorous activity 20 minutes (20)] contributed 1,978 knees; 267 (14%) had KL worsening.
  • In the multivariable model, age, sex, BMI, and pain, but neither sedentary activity (adjusted OR 0.99) nor moderate‐vigorous activity (adjusted OR 1.00) were associated with KL worsening.

Citation:

Jayabalan P, Kocherginsky M, Chang A, et al. Physical activity and worsening of radiographic findings in persons with or at higher risk of knee osteoarthritis. [Published online ahead of print September 20, 2018]. Arthritis Care Res. doi:10.1002/acr.23756.

This Week's Must Reads

Predictors of Discordance Between Patients with RA, Arthritis Care Res; ePub 2018 Nov 30; Challa, et al

Smoking Linked with Higher Disease Activity in RA, J Rheumatol; ePub 2018 Dec 1; Gianfrancesco, et al

Chronic Opioid Use Doubled Among Patients with RA, Arthritis Rheumatol; ePub 2018 Nov 26; Lee, et al

RA Telephone Education Program is Well Received, Musculoskeletal Care; ePub 2018 Dec 5; Farley, et al

Autoantibodies to PAD2 Linked with Less Severe RA, Front Immunol; ePub 2018 Nov 20; Darrah, et al

Must Reads in Lifestyle

Does Exercise Contribute to Radiographic Worsening?, Arthritis Care Res; ePub 2018 Sep 20; Jayabalan, et al

Smoking, Alcohol, and SLE Incidence Link Examined, Arthritis Care Res; ePub 2018 Aug 9; Cozier, et al

Resistance Training May Help Minimize Hip Bone Loss, J Bone Miner Res; ePub 2018 Aug 7; Beavers, et al