Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Flu Shot Can be Given Irrespective of the Time of Last Methotrexate Dose

Key clinical point: Patients with RA should stop methotrexate for 2 weeks after receiving an influenza vaccination, regardless of the time of their last dose prior to vaccination.

Major finding: Response to vaccine, fold increase in HI antibody titers, and postvaccination seroprotection rates were not associated with the time between the last methotrexate dose and the time of vaccination.

Study details: A post hoc analysis of a randomized, controlled trial involving 316 patients with rheumatoid arthritis who continued or stopped methotrexate for 2 weeks following influenza vaccination.

Disclosures: The study was sponsored by GC Pharma. One author disclosed serving as a consultant to Pfizer and receiving research grants from GC Pharma and Hanmi Pharma.


Park JK et al. Ann Rheum Dis. 2019 Mar 23. doi: 10.1136/annrheumdis-2019-215187