Clinical Edge

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Vitamin D Does Not Improve Bone Density, Structure in Healthy Patients

Key clinical point: Vitamin D supplementation does not improve bone density or structure in healthy men and women.

Major finding: There was no significant absolute percentage change over 2 years in areal bone mineral density of the whole body (P = .60) versus patients receiving placebo.

Study details: A subcohort of 771 older, healthy adults in the VITAL study who received vitamin D3 supplementation or placebo for 2 years.

Disclosures: The study was funded in part by grants from the National Cancer Institute, the National Heart, Lung and Blood Institute, the Office of Dietary Supplements, the National Institute of Neurological Disorders and Stroke, and the National Center for Complementary and Integrative Health. Dr. LeBoff reports receiving grants from the National Institute of Arthritis Musculoskeletal and Skin Diseases. Two authors reported nonfinancial support Pharmavite LLC of Northridge, Calif., Pronova BioPharma of Norway and BASF, and Quest Diagnostics. The remaining authors report no conflicts of interest.


LeBoff M et al. ASBMR 2019, Abstract 1046 and 1057.