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High-Dose Vitamin D for Bone Health May Do More Harm Than Good

Key clinical point: High-dose vitamin D supplementation does not appear to help maintain bone quality in healthy adults.

Major finding: Volumetric radial bone mineral density was significantly lower with 10,000 and 4,000 IU than it was with 400 IU of vitamin D3 for 3 years (–7.5 and –3.9 mg of calcium hydroxyapatite per cm3; mean percent changes, –3.5%, –2.4%, and –1.2%, respectively).

Study details: A double-blind randomized clinical trial of 311 adults.

Disclosures: This study was funded by Pure North S’Energy Foundation in response to an investigator-initiated research grant proposal. Dr. Burt reported having no disclosures.


Burt L et al. JAMA. 2019 Aug 27;322(8):736-45.