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CagA-positive H. pylori patients at higher risk of osteoporosis, fracture

Key clinical point: The cytotoxin associated gene-A strain of H. pylori appears to be a risk factor for fractures and bone loss.

Major finding: At follow-up, patients with CagA-positive strains had an increased risk of a clinical vertebral fracture (HR, 5.27; 95% CI, 2.23-12.63; P < .0001) or a nonvertebral incident fracture (HR, 2.09; 95% CI, 1.27-2.46; P < .01), compared to patients without H. pylori.

Study details: A prospective, population-based cohort study of 1,149 adults in Siena, Italy, between the ages of 50 and 80.

Disclosures: The study was supported in part by a grant from the Italian Association for Osteoporosis. The authors reported no potential conflicts of interest.


Gennari L et al. J Bone Miner Res. 2020 Aug 13. doi: 10.1002/jbmr.4162.