Key clinical point: The cytotoxin associated gene-A strain of H. pylori appears to be a risk factor for fractures and bone loss.
Major finding: At follow-up, patients with CagA-positive strains had an increased risk of a clinical vertebral fracture (HR, 5.27; 95% CI, 2.23-12.63; P < .0001) or a nonvertebral incident fracture (HR, 2.09; 95% CI, 1.27-2.46; P < .01), compared to patients without H. pylori.
Study details: A prospective, population-based cohort study of 1,149 adults in Siena, Italy, between the ages of 50 and 80.
Disclosures: The study was supported in part by a grant from the Italian Association for Osteoporosis. The authors reported no potential conflicts of interest.
Gennari L et al. J Bone Miner Res. 2020 Aug 13. doi: 10.1002/jbmr.4162.