Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Antibody Hierarchy May Drive Development of SLE vs Antiphospholipid Syndrome

Key clinical point: Antiphospholipid antibodies have differing influences on the manifestations of two important autoimmune diseases.

Major finding: Anticardiolipin antibodies conferred the highest risk for arterial thrombosis, she noted (odds ratio, 5.7), whereas lupus anticoagulant conferred the highest risk for venous thrombosis (OR, 4.7).

Study details: Data from 3,651 patients with systemic lupus erythematosus in the RELESSER registry, a multicenter, Spanish hospital-based registry, with retrospective, cross-sectional data collection.

Disclosures: Dr. Riancho Zarrabeitia has received travel grants from AbbVie, Pfizer, UCB, Merck, GlaxoSmithKline, Amgen, and Roche.


Riancho-Zarrabeitia L et al. Ann Rheum Dis. Jun 2019;78(Suppl 2):136-7. Abstract OP0124. doi: 10.1136/annrheumdis-2019-eular.2485.