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VEDOSS Study Describes Predictors of Progression to Systemic Sclerosis

Key clinical point: Patients with Raynaud’s phenomenon who progressed to systemic sclerosis within 5 years were more likely to have puffy fingers, disease-specific antibodies, or nailfold video capillaroscopy abnormalities.

Major finding: Disease-specific antibodies (relative risk, 5.4; 95% confidence interval, 3.7-7.9) and puffy fingers (RR, 3.0; 95% CI, 2.0-4.4) together were strongly predictive of progression from Raynaud’s phenomenon to systemic sclerosis (RR, 4.3; 95% CI, 2.6-7.3).

Study details: A longitudinal, observational study of which characteristics among 742 patients with Raynaud’s phenomenon predicted progression to systemic sclerosis within 5 years.

Disclosures: The investigators reported having no relevant conflicts of interest.


Bellando-Randone S et al. Arthritis Rheumatol. 2019;71(suppl 10). Abstract 2914.