Lower sleep efficiency and more minutes awake after sleep onset were independently associated with higher circulating levels of von Willebrand factor (VWF) antigen in women during midlife, a recent study found. Lower sleep efficiency was also associated with higher circulating levels of interleukin-6 (IL-6). Therefore, these findings suggest that sleep disturbances are associated with greater circulating inflammation in midlife women. 295 peri- and postmenopausal women aged 40–60 years completed 3 days of wrist actigraphy, physiologic hot flash monitoring, questionnaires (eg, Berlin sleep apnea risk questionnaire), and a blood draw for the assessment of inflammatory markers, including C-reactive protein (CRP), IL-6, and VWF antigen. Researchers found:
- In separate models controlling for age, race/ethnicity, and education, lower sleep efficiency was associated with higher IL-6 [b(SE) = .02 (.10)] and VWF [b(SE) = .02 (.08)].
- More minutes awake after sleep onset was associated with higher VWF [b(SE) = .12 (.06)].
- Findings persisted in multivariable models.
Nowakowski S, Matthews KA, von Känel R, Hall MH, Thurston RC. Sleep characteristics and inflammatory biomarkers among midlife women. [Published online ahead of print March 30, 2018]. Sleep. doi:10.1093/sleep/zsy049.
This Week's Must Reads
Inflammatory Diet Linked with Depressive Symptoms, J Affect Disord; ePub 2018 Apr 3; Shivappa, et al
Schizotypes and Social Cognition Task Performance , Psychiatry Res; ePub 2018 Apr 4; Pflum, Gooding
Loss of Control Eating and Metabolic Syndrome, Int J Eat Disord; ePub 2018 Apr 1; Shank, et al
Consanguineous Parents, Psychopathology of Progeny, JAMA Psychiatry; ePub 2018 Apr 4; Maguire, et al
Pornography Use and Relationship Satisfaction, J Sex Res; ePub 2018 Mar 26; Maas, et al
Must Reads in Sleep Medicine
Poor Sleep and Inflammatory Biomarkers Linked, Sleep; ePub 2018 Mar 30; Nowakowski, et al
Sleep, Trauma, and Psychosis-Like Experiences, Schizophr Res; ePub 2018 Mar 8; Andorko, et al
Poor Sleep and Non-Medical Prescription Drug Use , Behav Sleep Med; ePub 2017 Dec 22; Alamir, et al
Caregivers of PLWDs at Risk for Sleep Disturbances, Am J Geriatr Psych; ePub 2018 Feb 4; Polenick, et al
Alcohol Use Disorder and Sleep Disturbances, Behav Sleep Med; ePub 2018 Jan 29; Wallen, et al