Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Understanding Aprosody Severity in Schizophrenia

Schizophr Res; ePub 2018 Feb 12; Compton, et al

Findings from a recent study could represent a step toward developing new methods for measuring and tracking the severity of aprosody, or the lack of variations in speech, in schizophrenia, using acoustic phonetic parameters. Audio-recorded speech was obtained from 98 patients (including 25 with clinically rated aprosody and 29 without) and 102 unaffected controls using 5 tasks: 1 describing a drawing, 2 based on spontaneous speech elicited through a question (Tasks 2 and 3), and 2 based on reading prose excerpts (Tasks 4 and 5). Researchers compared groups on variation in pitch (F0), jaw/mouth opening and tongue height (F1) and tongue front/back position and/or lip rounding (F2), and intensity/loudness. They found:

  • Regarding pitch variation, patients with aprosody differed significantly from controls in Task 5 in both unadjusted tests and those adjusted for sociodemographics.
  • For the standard deviation (SD) of F1, no significant differences were found in adjusted tests.
  • Regarding SD of F2, patients with aprosody had lower values than controls in Task 3, 4, and 5.
  • For variation in intensity/loudness, patients with aprosody had lower values than patients without aprosody and controls across the 5 tasks.

Citation:

Compton MT, Lunden A, Cleary SD, et al. The aprosody of schizophrenia: Computationally derived acoustic phonetic underpinnings of monotone speech. [Published online ahead of print February 12, 2018]. Schizophr Res. doi:10.1016/j.schres.2018.01.007.

This Week's Must Reads

Depression May Be Linked with SLE Risk in Women, JAMA Psychiatry; ePub 2018 Sep 12; Roberts, et al

Women with MDD During the Childbearing Years, Depress Anxiety; ePub 2018 Sep 7; Freeman, et al

Resilience Examined in Older Adults with Depression, Am J Geriatr Psychiatry; ePub 2018 Aug 25; Laird, et al

Disparities in Depression Care Among Arab Americans, Depress Anxiety; ePub 2018 Aug 12; Dallo, et al

Telehealth vs In-Person Care for Depressed Veterans, J Clin Psychiatry; 2018 Aug 28; Egede, et al

Must Reads in Schizophrenia & Other Psychotic Disorders

FDA Approves Perseris for Schizophrenia, FDA news release; 2018 Jul 27

Gender Differences in Schizophrenia May Vary by Age, Am J Geriatr Psychiatry; ePub 2018 Jul 27; Muralidharan, et al

Folic Acid Exposure Linked with Psychosis Reduction, JAMA Psychiatry; ePub 2018 Jul 3; Eryilmaz, et al

FDA Approves New Dosing Formulation for Nuplazid, Acadia Pharmaceuticals Inc. news release; 2018 Jun 29

FDA Approves Initiation Drug for Schizophrenia, Alkermes plc news release; 2018 Jul 2