Long-range temporal correlations (LRTCs) act as markers of network instability in patients with schizophrenia, a new study found. Researchers sought to support the findings that alpha and beta frequency bands have weaker temporal stability in patients with schizophrenia with high-density electroencephalography (EEG), and to test associations with characteristic schizophrenia symptoms and cognitive deficits. A 128-channel EEG was used to record eyes-open resting state brain activity of 23 people with schizophrenia and 24 matched healthy controls (HCs). Among the findings:
- Patients with schizophrenia demonstrated an area of significantly reduced beta-band LRTC compared with HCs over bilateral posterior regions.
- There were no between-group differences in alpha-band activity.
- Individual symptoms of schizophrenia were not related to LRTC values nor were cognitive deficits.
Moran JK, et al. Long-range temporal correlations in resting state beta oscillations are reduced in schizophrenia. [Published online ahead of print July 19, 2019]. Front Psychiatry. doi: 10.3389/fpsyt.2019.00517.