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Smooth Pursuit Eye Tracking and Schizophrenia

Early pursuit gain and predictive gain measured

Smooth pursuit eye tracking deficits serve as an intermediate phenotype for schizophrenia and potentially for psychotic disorders. The Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium took a closer look in a study involving 1,775 individuals.

Participants included the following probands:

• Schizophrenia (n = 265)

• Schizoaffective disorder (n = 178)

• Psychotic bipolar disorder (n = 231)

• Their first-degree relatives (n = 306, n = 217, n = 273, respectively)

• Healthy controls (n = 305)

Among the results:

• Probands from all diagnostic groups were impaired on all pursuit measures vs controls.

• Those with schizophrenia were more impaired than other groups on both early pursuit gain and predictive gain.

• Relatives with and without enhanced psychosis spectrum personality traits were impaired on initial eye acceleration, but not on pursuit gain measures.

• There were no differences in pursuit measures between those in the 3 first-degree relative groups.

Citation: Lencer R, Sprenger A, Reilly J, et al. Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study. Schizophr Res. 2015; October 15, 2015. doi: