Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Psychosis and Innate Immunity

Surprising findings in those with recent onset

Recent onset of psychosis could be linked with inherent deficits in innate immunity, whereas those with later-stage disease may have increased levels of innate immunity, according to a study of 588 individuals.

Participants included 79 with recent onset psychosis, 249 with chronic schizophrenia, and 260 controls. Investigators calculated a combined inflammation score by analyzing blood samples for levels of C-reactive protein, Pentraxin 3, and IgG antibodies to gliadin, casein, and Saccharomyces cerevisiae.

Those with chronic schizophrenia had significant elevations in the combined inflammation score vs controls. They had significantly increased odds of a combined inflammation score greater than the 75th and 90th percentile level of controls.

Those with recent onset showed a reduced combined score. They had significantly increased odds of a combined inflammation score <10th and 25th percentile level of the controls.

The authors noted that the reasons for these changes could be due to compensatory increases as the disease advances.

Citation: Dickerson F, Stallings C, Origoni A, et al. Inflammatory markers in recent onset psychosis and chronic schizophrenia. Schizophr Bull. 2016;42(1):134-141.