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Predictors of suicide in schizophrenia spectrum disorders

Key clinical point: Psychiatric hospitalizations, drug use and mood disorders, suicide attempts before diagnosis, and later age at first diagnosis are predictors of suicide in patients diagnosed with schizophrenia spectrum disorders (SSD).

Major finding: Age 26-35 years (HR, 1.27; P less than .001) and 36-45 years (HR, 1.34; P less than .001) vs. age 16-25 years, male sex (HR, 2.00; P less than .001), previous suicide-related behavior requiring emergency care or hospitalization (HR, 2.23; P less than .001), drug use disorder (HR, 1.21; P = .011), mood disorder diagnosis (HR, 1.32; P less than .001), or mental health hospitalization (HR, 1.30; P less than .001) were predictors of suicide in the 2 years before diagnosis of SSD.

Study details: This is a 20-year population study involving 75,989 individuals with newly diagnosed SSD.

Disclosures: The study was funded by the Medical Psychiatry Alliance, the Centre for Addiction and Mental Health, the Hospital for Sick Children, Trillium Health Partners, the Ontario Ministry of Health and Long-Term Care (MOHLTC), and an anonymous donor. It was also supported by the Institute for Clinical Evaluative Sciences, which is funded by an annual grant from the MOHLTC. The authors declared no conflicts of interest.


Zaheer J et al. Schizophr Res. 2020 Jun 2. doi: 10.1016/j.schres.2020.04.025.