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Motivational Deficits in Schizophrenia Examined

Cogn Affect Behav Neurosci; 2018 Dec; Hernaus, et al

Recent findings point to an impairment in learning rate modulation in people with schizophrenia (PSZ), leading to a reduced ability to adjust task behavior in response to unexpected outcomes. Learning rate modulation deficits may be associated with decreased involvement of the dorsomedial prefrontal cortex (dmPFC) within a greater reinforcement learning network. 26 PSZ and 23 healthy volunteers completed a probabilistic reinforcement learning paradigm with occasional, sudden, shifts in contingencies. Researchers found:

  • Using computational modeling, evidence was found of an impairment in trial-wise learning rate modulation (α) in PSZ before and after a reinforcement contingency shift, expressed most in PSZ with more severe motivational deficits.
  • In a subsample of 22 PSZ and 22 healthy volunteers, there was little evidence for between-group differences in ventral striatum reward prediction error (VS RPE) signals and dmPFC learning rate signals, as measured with functional magnetic resonance imaging.
  • However, a follow-up psychophysiological interaction analysis revealed decreased dmPFC-VS connectivity concurrent with learning rate modulation, most prominently in individuals with the most severe motivational deficits.
Citation:

Hernaus D, Xu Z, Brown EC, et al. Motivational deficits in schizophrenia relate to abnormalities in cortical learning rate signals. Cogn Affect Behav Neurosci. 2018;18:1338. doi:10.3758/s13415-018-0643-z.

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Must Reads in Schizophrenia & Other Psychotic Disorders

Motivational Deficits in Schizophrenia Examined, Cogn Affect Behav Neurosci; 2018 Dec; Hernaus, et al

Medical Comorbidity, Mortality in Schizophrenia, Schizophr Res; ePub 2018 Dec 6; Brink, et al

Illness Awareness in Older Adults with Schizophrenia, Am J Geriatr Psychiatry; ePub 2018 Oct 21; Cohen, et al

Smartphone Program Aids Patients with Schizophrenia , Schizophr Res; ePub 2018 Dec 11; Achtyes, et al

Polygenic Risk Score Can Predict Drug Effectiveness, Am J Psychiatry; ePub 2018 Nov 5; Zhang, et al