Key clinical point: Low levels of serum folate may be a risk factor for schizophrenia, irrespective of gender.
Major finding: Analysis of covariance by gender showed lower levels of serum folate in both male and female patients with schizophrenia (F [1, 716] = 140.6; P = 9.6 × 10−30 and F [1, 1088] = 191.6; P = 2.9 × 10−40, respectively) compared with the controls.
Study details: Serum folate levels were assessed in 482 Japanese patients with schizophrenia and 1,350 nonpsychiatric controls.
Disclosures: This work was partly supported by the Japan Agency for Medical Research and Development and the Japan Society for the Promotion of Science KAKENHI. T Ohmori, S Numata, M Nakataki, SY Watanabe, M Kinoshita, and Y Tomioka reported relationships with multiple pharmaceutical companies. Other authors declared no conflicts of interest
Tomioka Y et al. Psychiatry Clin Neurosci. 2020 May 23. doi: 10.1111/pcn.13074.