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Low folate levels are a risk factor for schizophrenia regardless of gender

Key clinical point: Low levels of serum folate may be a risk factor for schizophrenia, irrespective of gender.

Major finding: Analysis of covariance by gender showed lower levels of serum folate in both male and female patients with schizophrenia (F [1, 716] = 140.6; P = 9.6 × 10−30 and F [1, 1088] = 191.6; P = 2.9 × 10−40, respectively) compared with the controls.

Study details: Serum folate levels were assessed in 482 Japanese patients with schizophrenia and 1,350 nonpsychiatric controls.

Disclosures: This work was partly supported by the Japan Agency for Medical Research and Development and the Japan Society for the Promotion of Science KAKENHI. T Ohmori, S Numata, M Nakataki, SY Watanabe, M Kinoshita, and Y Tomioka reported relationships with multiple pharmaceutical companies. Other authors declared no conflicts of interest


Tomioka Y et al. Psychiatry Clin Neurosci. 2020 May 23. doi: 10.1111/pcn.13074.