Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Individual Treatment Response in Schizophrenia

Individual differences in antipsychotic drug response may exist in patients with schizophrenia, but the assumption of a personal element of response to treatment is not clear. This according to a meta-analysis of 52 randomized clinical trials (RCTs). The outcome measure was the overall variability ratio of treatment to control. Researchers found:

  • An RCT was simulated, comprising 30 patients with schizophrenia randomized to either the treatment group or the control group.
  • Additionally, the variability ratio was assessed in 15,360 patients with a schizophrenia or schizoaffective diagnosis.
  • The variability was slightly lower in the treatment group vs the control group.


Winkelbeiner S, et al. Evaluation of Differences in individual treatment response in schizophrenia spectrum disorders: A meta-analysis. [Published online ahead of print June 3, 2019]. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2019.1530.