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GM Abnormalities in Language Processing Areas May Underlie Verbal Challenges in Early Illness

Key clinical point: The gray matter (GM) volumes of the left sides of the pars opercularis, pars triangularis, planum temporale, Heschl’s gyrus, insula, and fusiform gyrus are significantly smaller in schizophrenia patients, compared with healthy controls. No significant volume differences were noted in the right-side volumes between the groups.

Major finding: Several language processing areas had correlations between low gray matter volume on the left side and schizophrenia, notably the fusiform gyrus and severity of auditory verbal hallucinations, the planum temporale and severity of positive formal thought and delusions, and the insula and severe bizarre behavior.

Study details: The data come from 94 adults with a diagnosis of first-episode schizophrenia and 52 healthy controls.

Disclosures: The researchers disclosed having no financial conflicts. The study was supported by the 2018 Research Fund of the Korean Society for Schizophrenia Research, Republic of Korea.


Jung S et al. Neuroimage Clin. 2019. doi: 10.1016/j.nicl.2019.102022.