Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Genetic liability to schizophrenia tied to childhood trauma

Key clinical point: Genetic liability to schizophrenia in mothers and children is associated with exposure to traumatic events during childhood and adolescence.

Major finding: The Avon Longitudinal Study of Parents and Children (ALSPAC) revealed that schizophrenia polygenic scores (PGSs) of both children (n = 7,426; odds ratio [OR], 1.14) and mothers (n = 7,380; OR, 1.13) were positively associated with exposure to trauma across childhood and adolescence (age range, 0-17 years). Similar results were observed in the Norwegian Mother, Father, and Child Cohort Study (MoBa) at age 8 years (children: n = 7,244; OR, 1.08; mothers: n = 7,009; OR, 1.10).

Study details: The study used data from 2 international birth cohorts (ALSPAC and MoBa) to evaluate the association between PGS for schizophrenia and childhood trauma exposure.

Disclosures: The study was supported by the Medical Research Council and the University of Bristol and by the National Institute for Health Research (NIHR) Biomedical Research Centre at the University Hospitals Bristol National Health Service Foundation Trust and the University of Bristol. The authors declared no conflicts of interest.


Sallis HM et al. Psychol Med. 2020 Apr 01. doi: 10.1017/S0033291720000537.