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Functional Network Connectivity & Cognitive Deficits in Schizophrenia

Patients with schizophrenia demonstrated significant reduction in several function connectivity (FC) networks that may partially underlie some of the core neurocognitive deficits in schizophrenia, a new study found. Researchers evaluated the integrity of major functional networks and assessed their role in supporting 2 cognitive functions affected in schizophrenia: processing speed (PS) and working memory (WM). Resting-state functional magnetic resonance imaging (rsfMRI) data from 261 patients and 337 controls, were aggregated from 3 independent cohorts and evaluated. Among the findings:

  • Patients showed consistent patterns of cognitive and resting state FC (rsFC) deficits across 3 cohorts.
  • Patient-control differences in rsFC calculated using seed-based and dual-regression approaches were consistent.
  • RsFC measures explained 12-17% of the individual variations in PS and WM in the full sample and in default-mode networks.


Adhikari BM, et al. Functional network connectivity impairments and core cognitive deficits in schizophrenia. [Published online ahead of print July 16, 2019]. Hum Brain Mapp. doi: 10.1002/hbm.24723.