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Diabetic complications do not seem to explain the excess mortality in schizophrenia

Key clinical point: The mortality rate is higher in patients with schizophrenia and diabetes compared to those with diabetes only, irrespective of diabetic complications, indicating that diabetic complications cannot explain the higher mortality.

Major finding: The incidence of diabetic complications was similar in female patients with schizophrenia and diabetes vs. in those with diabetes only (incidence rate ratio [IRR], 0.93), and significantly lower in male patients (IRR, 0.85). All-cause mortality for individuals with a diabetic complication was higher in those with schizophrenia (mortality rate ratio [MRR], 1.92 for females; MRR, 1.69 for males). The mortality rate was higher in patients with schizophrenia without diabetic complications (MRRs, 2.01 for female and 1.71 for male patients).

Study details: Population-based cohort study of 239,118 Danish patients diagnosed with diabetes between 1997 and 2017.

Disclosures: This study was supported by The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark, Mental Health in Primary Care (MEPRICA) supported by the Lundbeck Foundation, and Centre for Integrated Register-based Research (CIRRAU), both at Aarhus University, Denmark. The authors declared no conflict of interest.


Toender A et al. Schizophr Res. 2020 Feb 3. doi: 10.1016/j.schres.2020.01.024.