Clinical Edge

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Cognitive Training Program in Schizophrenia

Schizophr Res; ePub 2019 Mar 28; Mahncke, et al

No cognitive or functional capacity benefit was determined from the implementation of a computerized cognitive training program in people with schizophrenia, a new study found. The 26-week randomized blinded placebo-controlled trial included 150 participants who were randomized to experimental or active control groups. Training was conducted in-clinic, with an intended training schedule of 5 days per week, 1 hour per day, for 26 weeks. Co-primary outcome measures were the MATRICS Consensus Cognitive Battery (MCCB) composite score and the UCSD Performance-Based Skills Assessment (UPSA-2) total score. Researchers found:

  • The groups were well matched at baseline.
  • No significant effect of the experimental treatment was observed on the primary or secondary outcome measures compared to the active control.
  • Review of the task learning/target engagement data suggested inadequate engagement.


Mahncke HW, Kim SJ, Rose A, et al. Evaluation of a plasticity-based cognitive training program in schizophrenia: Results from the eCaesar trial. [Published online ahead of print March 28, 2019]. Schizophr Res. doi:10.1016/j.schres.2019.03.006.