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Brain Function, Structure, and Genomic Data Linked in Schizophrenia

Key clinical point: The correlation among gray matter volume, functional connectivity, and particular genes was significant in multivariate analysis. Also, decreased functional connectivity was related to lower gray matter volume, with both showing greater deficits at later stages of disease.

Major finding: Gray matter volume and functional connectivity were impaired in the hippocampus, temporal gyrus and cerebellum in adults with schizophrenia, and those impairments correlated with several genes, including SATB2, GABBR2, PDE4B, and CACNA1C.

Study details: The data come from imaging and gene analysis of 159 adults, including 52 patients with chronic schizophrenia, 20 drug-naïve patients with first-episode schizophrenia, and 87 healthy controls.

Disclosures: The researchers had no financial conflicts. The study was supported by several entities, including the Natural Science Foundation of China, the Strategic Priority Research Program of the Chinese Academy of Sciences, the Beijing Municipal Science and Technology Commission, and the National Institutes of Health.

Citation:

Luo N et al. Neuroimage Clin. 2019. doi: 10.1016/j.nicl.2019.101887.