Those with brief limited intermittent psychotic symptoms (BLIPS) should be placed in their own risk subgroup separate from those with attenuated psychotic symptoms, according to a meta-analysis involving 33 independent studies comprising 4,227 individuals.
Investigators looked for the presence of psychosis in studies of those at clinical high risk (CHR) who reported their risk according to the presence of: BLIPS; attenuated psychotic symptoms (APS) and genetic risk and deterioration syndrome (GRD); APS alone; GRD alone; basic symptoms; and CHR.
Among the results:
• There were no significant differences in psychosis risk between the APS and GRD and the APS-alone subgroups.
• Those in the BLIPS subgroup had a higher risk of psychosis than the APS and GRD-alone subgroups at 24, 36, and 48 or more months of follow-up.
• Those in the GRD subgroup did not have a higher risk of psychosis than the CHR subgroup.
• There were not enough studies of the remaining subgroups to allow valid conclusions to be drawn.
Citation: Fusar-Poli P, Cappucciati M, Borgwadt S, et al. Heterogeneity of psychosis risk within individuals at clinical high risk: A meta-analytical stratification. [Published online ahead of print December 30, 2015]. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2015.232.