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Ratio of Plasma BDNF To Leptin Levels in MDD

A relatively higher ratio of pretreatment plasma brain-derived neurotrophic factor (pBDNF) to leptin was associated with greater response in major depressive disorder (MDD) but not in panic disorder (PD), a new study found. 41 patients with MDD, 52 patients and PD, and 59 matched healthy controls were recruited in the 12-week follow-up study. All patients completed 5 visits and both MDD and PD patients had standard pharmacotherapy for 12 weeks. Among the findings:

  • The ratio of pBDNF to leptin was significantly lower in patients with MDD and PD vs healthy controls, but was not associated with severity of depressive or anxiety symptoms.
  • pBDNF:leptin ratio was significantly higher in responders than in nonresponders in MDD but not in PD.
  • In multivariate analysis, pBDNF:leptin ratio was significantly associated with responsiveness.

Citation:

An JH, et al. Ratio of plasma BDNF to leptin levels are associated with response in major depressive disorder but not in panic disorder: a 12-week follow-up study. [Published online ahead of print August 14, 2019]. J Affective Dis. doi:10.1016/j.jad.2019.08.021.