Clinical Edge

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More Data Confirm Links Between Depression, Inflammatory Markers

Key clinical point: Measurements of hedonic well-being and eudemonic well-being are associated with lower white blood cell (WBC) counts in older adults; eudemonic well-being also is associated with lower levels of fibrinogen and C-reactive protein (CRP).

Major finding: Eudemonic well-being is associated with lower WBC, CRP, and fibrinogen, particularly in older men.

Study details: The data come from a study of 8,780 adults aged 50 years and older who were enrolled in the English Longitudinal Study of Ageing.

Disclosures: The researchers disclosed no financial conflicts. Daisy Fancourt, PhD, is supported in part by the Wellcome Trust.


Fancourt D and Steptoe A. Brain Behav Immun. 2019. doi: 10.1016/j.bbi.2019.10.004.