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MDD: Vitamin D supplementation may reduce negative symptoms

Key clinical point: Vitamin D supplementation may reduce negative emotions in patients with major depressive disorder (MDD).

Major finding: Vitamin D supplementation reduced negative emotions at doses of ≤4,000 IU/day (Hedges' g = −0.2311; P = .0008). In the sub-group analysis, the effects were significant in patients with serum levels of 25(OH)D ≤50 nmol/L (P = .0028), but not in those with levels >50 nmol/L (P = .0507).

Study details: Systematic review and meta-analysis of 25 randomized controlled trials (n = 7,534) comparing the effects of vitamin D and the placebo on negative emotions in patients with MDD.

Disclosures: No funding information was identified. The authors declared no conflicts of interest.

Citation:

Cheng YC et al. Depress Anxiety. 2020 May 04. doi: 10.1002/da.23025.