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MDD: Verbal learning deficit may be a potential marker for suicide risk

Key clinical point: Patients with major depressive disorder (MDD) having suicidal ideation (SI) show poorer performance in verbal learning domain.

Major finding: The SI vs. non-SI group performed worse in the domain of verbal learning at baseline (mean verbal learning scores, 39.7 vs. 42.2; P = .036). Other cognitive domains had no significant differences between the groups (speed of processing, working memory, and visual learning; P greater than .005 for all).

Study details: The data come from a longitudinal, 4-week open-label trial of patients with MDD (SI group, n = 130 and non-SI group, n = 175).

Disclosures: This study was funded by the National Natural Science Foundation of China, the National Key Research and Development Program of China, Guangdong Basic and Applied Basic Research Foundation, Science and Technology Department of Guangdong Province major science and technology, the International Communication Foundation Science and Technology Commission of Shanghai Municipality, Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory, and Key Laboratory for Innovation platform Plan, Science, and Technology Program of Guangzhou, China. The authors declared no conflicts of interest.


Lan X et al. J Affect Disord. 2020 Apr 30. doi: 10.1016/j.jad.2020.03.141.