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MDD: Self-criticism may predict the course of illness in severely disturbed patients

Key clinical point: A psychotherapeutic focus on a reduction of self-criticism is warranted in severely disturbed patients with major depressive disorder (MDD).

Major finding: Change in self-criticism was the most relevant predictor for a lower risk for relapse and a positive outcome after 1 year; less change in self-criticism being associated with lower improvements over time.

Study details: A secondary analysis of the INDDEP-study assessed 518 severely disturbed patients (mean age, 44.0 years) who needed hospital treatment for MDD.

Disclosures: The original INDDEP-study was funded by the Heidehofstiftung GmbH Stuttgart. The authors declared no conflicts of interest.


Zeeck A et al. Front Psychiatry. 2020 Mar 12. doi: 10.3389/fpsyt.2020.00147.