Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Levels of Inflammation in Patients with MDD

Studies targeting inflammation to treat major depressive disorder (MDD) often fail to assess baseline levels and significantly reduce inflammation following intervention, a new study found. The systematic review included randomized controlled trials (RCTs) related to the use of anti-inflammatory treatment strategies in individuals who demonstrated elevated concentrations of inflammatory mediators. Among the findings:

  • 51 RCTs were identified, of which 43 were excluded following full-text screening.
  • 8 trials involving 437 individuals were included; 5 utilized anti-inflammatories, 2 utilized omega-3 fatty acids, and 1 utilized exercise and meditation.
  • Only the trial related to exercise and meditation demonstrated both an elevation in baseline inflammation and a significant reduction in inflammation following intervention.

Citation:

Allison DJ, Sharma B, Timmons BW. The efficacy of anti-inflammatory treatment interventions on depression in individuals with major depressive disorder and high levels on inflammation: A systematic review of randomized clinical trials. [Published online ahead of print May 9, 2019]. Physiol Behav. doi: 10.1016/j.physbeh.2019.05.006.