Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Higher Frequency of Cannabis Use Tied to Lower Rates of MDD Among Adolescents

Key clinical point: Major depressive disorder (MDD) is prevalent among adolescents with cannabis use; however, a higher frequency of use is associated with lower rates of MDD.

Major finding: Rates of lifetime and past year MDD, MDD with severe role impairment, and past year suicide attempt were significantly higher among adolescents with any history of cannabis use vs. never users (P less than .001). The predicted prevalence of lifetime MDD was significantly lower in heavy users vs. light users and those who abstained in the past year (0.172 vs. 0.222 vs. 0.243).

Study details: The findings are based on the results of the National Survey on Drug Use and Health including 14,873 adolescents with a history of cannabis use and 73,079 never users.

Disclosures: This study was supported by the National Institute on Drug Abuse. Dr Gukasyan had no conflicts to declare and Dr. Strain had consulted, worked for, or served on advisory boards to the following organizations: Analgesic Solutions, Caron, Indivior, Medscape, The Oak Group, Otsuka, Pinney Associates, and Up To Date.


Gukasyan N et al. Drug Alcohol Depend. 2020 Jan 16. doi: 10.1016/j.drugalcdep.2020.107867.