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Gut microbiome differences in treatment resistant depression

Key clinical point: The gut microbiome of patients with treatment resistant depression and major depressive disorder differs from healthy controls.

Major finding: Researchers found a statistically significant overrepresentation of Paenibacillaceae in patients with MDD, compared to controls. Additionally, there were a number of bacteria found in treatment-resistant patients but not in treatment-responsive patients, including Thaumarchaeota, Yersinia and its species Yersinia pseudotuberculosis, Peptococcus, Fenollaria timonensis, Blautia sp. canine oral taxon 337, and Papillibacter cinnamivorans.

Study details: The study involved 34 patients with MDD and 20 healthy controls.

Disclosures: The authors declare no conflict of interest.

Source: Fontana A, Manchia M, et al. Biomedicines. 2020; 8(9):311. doi.org/10.3390/biomedicines8090311