The risk of hypertension was significantly greater in male patients with major depressive disorder (MDD) compared with female patients with MDD, a new study found. A total of 743,114 outpatients were included in the study and were stratified by age, hospital level, insurance amount, and Charlson Comorbidity Index score. Among the findings:
- The hazard ratio of hypertension was significantly greater in male outpatients with MDD (HR=1.116) compared with female outpatients with MDD (HR=0.93).
- In a nested case-control study, female outpatients with MDD had lower risks of hypertension.
- Outpatients with MDD who used antidepressants had a higher risk of hypertension.
Kao WT, et al. Gender disparity in the risk of hypertension in subjects with major depressive disorder. [Published online ahead of print August 2, 2019]. Front Psychiatry. doi: 10.3389/fpsyt.2019.00541.