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Gender Disparity in Risk of Hypertension in Patients with MDD

The risk of hypertension was significantly greater in male patients with major depressive disorder (MDD) compared with female patients with MDD, a new study found. A total of 743,114 outpatients were included in the study and were stratified by age, hospital level, insurance amount, and Charlson Comorbidity Index score. Among the findings:

  • The hazard ratio of hypertension was significantly greater in male outpatients with MDD (HR=1.116) compared with female outpatients with MDD (HR=0.93).
  • In a nested case-control study, female outpatients with MDD had lower risks of hypertension.
  • Outpatients with MDD who used antidepressants had a higher risk of hypertension.


Kao WT, et al. Gender disparity in the risk of hypertension in subjects with major depressive disorder. [Published online ahead of print August 2, 2019]. Front Psychiatry. doi: 10.3389/fpsyt.2019.00541.