Clinical Edge

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Diabetes, Arthritis Have Greatest Impact on MDD Risk

Key clinical point: Diabetes mellitus and rheumatoid arthritis have the highest association with risk of major depressive disorder (MDD) out of 24 chronic conditions.

Major finding: For individuals older than 60 years, rheumatoid arthritis/osteoarthritis had the highest relative influence on MDD risk (10%); for individuals aged 60 years and younger, diabetes had the highest contribution to MDD risk, 13% and 10%, respectively, for those aged 45 years and younger, and those aged 46-60 years.

Study details: The data come from a review of 11,375 incident cases of MDD identified between 2000 and 2013.

Disclosures: The study was supported in part by the Agency for Healthcare Research and Quality and the National Institutes of Health. The researchers disclosed no financial conflicts.


Ryu E et al. BMC Psychiatry. 2016. doi: 10.1186/s12888-016-0821-x.