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Gender Differences in Schizophrenia May Vary by Age

Am J Geriatr Psychiatry; ePub 2018 Jul 27; Muralidharan, et al

Gender differences among adults with schizophrenia may vary depending on age, according to a recent study. In addition, gender differences on negative symptoms may vary by symptom subgroup. Community-dwelling adults (n=242, aged 40-85) with schizophrenia/schizoaffective disorder completed assessments of negative symptoms (expressive and experiential deficits), neurocognition, and social skills. Mann-Whitney U tests examined gender differences; a regression-based bootstrapped approach to moderation examined gender by age interactions. Researchers found:

  • Female participants had better neurocognition (U= 6,814.00) and less severe experiential deficits (U=4,130.50).
  • There was no gender difference on social skills (U=5,920.50).
  • Older age was associated with greater expressive deficits among men but not women (b= -.04).

Muralidharan A, Harvey PD, Bowie CR. Associations of age and gender with negative symptom factors and functioning among middle-aged and older adults with schizophrenia. [Published online ahead of print July 27, 2018]. Am J Geriatr Psychiatry. doi:10.1016/j.jagp.2018.07.006.