Clinical Edge

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Telomere Length at Midlife and Subsequent Depression

Key clinical point: In healthy women, longer telomeres at midlife are associated with significantly lower risk of a subsequent trajectory of worsening mood symptoms over 20 years.

Major finding: Among 4 depressive symptom trajectory groups, longer midlife relative telomere lengths were related to significantly lower odds of being in the worsening symptoms trajectory vs minimal trajectory, but not to other trajectories.

Study details: Depressive symptoms measured every 4 years among 8,801 women from the Nurses’ Health Study.

Disclosures: The study was funded by the National Institute of Mental Health, National Institute for Occupational Safety and Health, and the National Research Service Award.


Gillis JC et al. Depression and Anxiety. 2019 Apr 8. doi: 10.1002/da.22892.