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Supplementation, Food-Related Therapy for MDD?

JAMA; 2019 Mar 5; Bot, Brouwer, Roca, et al

Among overweight or obese adults with subsyndromal depressive symptoms, multinutrient supplementation compared with placebo and food-related behavioral activation therapy, compared with no therapy, did not reduce episodes of major depressive disorder (MDD) during 1 year, according to a recent study. This multicenter, 2 × 2 factorial, randomized clinical trial included overweight adults (BMI: 25-40) with elevated depressive symptoms and no MDD episode in the past 6 months. A total of 1,025 adults were randomized (July 30, 2015-October 12, 2016) and followed up for 1 year. Researchers found:

  • Among total participants (mean age, 46.5 years; 772 women [75%]; mean BMI, 31.4), 779 (76%) completed the trial.
  • During the 12-month follow-up, 105 (10%) developed MDD: 25 (9.7%) patients in the placebo without therapy, 26 (10.2%) in the placebo with therapy, 32 (12.5%) in the supplement without therapy, and 22 (8.6%) in the supplement with therapy group.
  • None of the treatment strategies affected MDD onset.
  • The odds ratio (OR) for supplements was 1.06; for therapy, 0.93; and for their combination, 0.93.


Bot M, Brouwer IA, Roca M, et al. Effect of multinutrient supplementation and food-related behavioral activation therapy on prevention of major depressive disorder among overweight or obese adults with subsyndromal depressive symptoms. The MooDFOOD randomized clinical trial. [Published online ahead of print March 5, 2019]. JAMA. 2019;321(9):858-868. doi:10.1001/jama.2019.0556.