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Slow-Wave Activity Tied to Mood Disturbance in MDD

Key clinical point: A lower delta sleep ratio (used to measure the distribution of slow-wave brain activity during sleep) was a significant predictor of mood disturbance among patients with major depressive disorder during a sleep delay challenge based on the Profile of Mood States-Short Form.

Major finding: The researchers found significantly greater slow-wave activity at baseline and after a sleep delay in the healthy controls (higher delta sleep ratios) compared with the depressed patients (P less than 0.01), and found that depressed patients showed less mood disturbance if they had higher delta sleep ratios.

Study details: The data come from 37 depressed adults aged 20-40 years and 59 healthy controls.

Disclosures: The study was supported by the National Institute of Mental Health. The researchers had no financial conflicts to disclose.


Goldschmied J et al. Psychol Med. 2019. doi: 10.1017/S0033291718001332.